ÿþ<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Strict//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-strict.dtd"> <html xmlns="http://www.w3.org/1999/xhtml" xml:lang="en" lang="en"> <head> <meta http-equiv="content-type" content="text/html; charset=iso-8859-1" /> <title>Kuan Yan LIACS HomePage </title> <meta http-equiv="content-language" content="en" /> <style type="text/css" media="screen,print"> @import "fjvprivate.css"; </style> </head> <body> <div id="main"> <!------ header ------> <div id="header"> <table width="100%" border="0"> <tr> <td><img src="IMAGES/logouln.gif" alt="Logo Leiden University" name="Leiden University" width="145" height="156" align="top" /> <h1>Kuan Yan</h1> <p class="sub">Section Imaging &amp; Bioinformatics</p></td> <td align="center" valign="middle"><div align="center"> <img alt="kuan yan LIACS" src="IMAGES/DSCN0734-mutation.bmp" style="height: 242px; width: 224px" /></div></td> </tr> </table> <p class="sub"><i>Leiden Institute of Advanced Computer Science</i></p> </div> <div id="content"> <!------ Page Contents ------> <div class="contentleft"> <h2>Page Contents</h2> <ul> <li><a href="#Affiliations">Affiliations</a></li> <li><a href="#Notes">Notes</a></li> <li><a href="#Aboutme">Biography</a></li> <li><a href="#Research Interests">Research Areas</a></li> <li><a href="#Publication">Publication</a></li> <!-- <li>voeg hier meer toe</li> --> </ul> <br> <br> <br> <br> <br> </div> <!------ Course Personnel ------> <div class="contentright"> <a name="Affiliations"></a> <h2>Contact, Imaging &amp; Bioinformatics</h2> <dl> <dd>Kuan Yan</dd> <dd>LIACS, Leiden University</dd> <dd>Niels Bohrweg 1</dd> <dd>2333 CA Leiden</dd> <dd>The Netherlands </dd> <dd>Office <b>107</b>, Snellius Building</dd> <dd>Phone +31 - (0)71 - 527 8920 </dd> <dd>Fax +31 - </dd> <dd>Email <a href="mailto:kyan@liacs.nl">Kuan Yan</a></dd> <dd>URL <a href="http://bio-imaging.liacs.nl" class="sub"&nbsp>Bio-Imaging Group</a></dd> </dl> </div> <!------ meer ------> <div class="mark contentblock"> <a name="Notes"></a> <h2>Notes</h2> <p>Tested for Netscape 7.x, Mozilla 1.7.*, Explorer 6.x, and Opera 7.x. Earlier versions of these browsers may cause improper response and/or errors.</p> <p>Pages last edited, Auguest 22<sup>th</sup> 2011.</p> <p>&nbsp;</p> </div> <p /> <div class="contentblock"> <a name="Aboutme"></a> <h2>Biography</h2> <dl> <dt>I was born in Shanghai, China 1982 Dec 30. Although being raised up in a big family of medical doctors, I have no intension to follow the tradition. Bioinformatics seems to be a decent compromise between my own interests and my parents&#39; expectation. Being believed to be one of the most frontline research field, Bioinformatics will eventually dominate the research of biology and Biochemical.</dt> <dt>Education Background</dt> <dd> <li>Jun 2008 - present: PhD student, LIACS, Leiden University</li> <li>Sep 2006 - Jun 2008: Master of Computer Science (Bioinformatics), Leiden University</li> <li>Sep 2002 - Jun 2006: Bachelor of Engineer (Information Technology), Hogoschool INHOLLAND</li> </dd> </dl> </div> <div class="contentblock"> <a name="Research Interests"></a> <h2>Research Areas</h2> <dl> <dt><i>Cell Tracking and Cellular Phenotypic Measurement in Tumor Cell Visualized by Time-lapse Microscope Video</i></dt> <dd> By revealing the correlation between gene mutation and cellular phenotype, a more objective and accurate estimation of gene pathway can be formalized in current cancer research. However, unlike more compact cell model such as red blood cell, tumor cell is highly motile and highly metastatic. It is posing a great challenge to the robustness and efficiency of existing tracking algorithms. Using cell tracking, working hour of post-experiment is reduced by 300% and accuracy of phenotype estimation is increased to 80%. <br /> <a href="IMAGES/tracked_sample.gif" target="_blank"> <img alt="cell tracking sample metastatic cancer" src="IMAGES/tracked_sample.gif" style="width: 256px; height: 256px" title="Tracking Result" border="0" /></a> <a href="IMAGES/trajectory.bmp" target="_blank"> <img alt="cell tracking sample trajectory metastatic cancer" src="IMAGES/trajectory.bmp" style="width: 256px; height: 256px" title="Trajectory" border="0" /><br /></a> Kuan Yan (copyright 2008)<p /> </dd> <dt><i>Correlation Establishing between Structural Phenotype and Cellular Phenotype</i></dt> <dd> The success in cell tracking encourages us to extend the research into cellular structure such as focal adhesion (FA). By establishing the correlation between cellular phenotype and structural phenotype, we may provide a new methodology of gene annotation and ontology construction. Our current results show a positive feedback from experimental siRNA screen data. <br /> <a href="IMAGES/Focal Adhesion all trajectories.bmp" target="_blank"> <img alt="focal adhesion tracking sample trajectory" src="IMAGES/Focal Adhesion all trajectories.bmp" style="width: 256px; height: 256px" border=0/></a> <a href="IMAGES/control + vinc movie 2t01xy2c1.gif" target="_blank"> <img alt="live image focal adhesion tracking" src="IMAGES/control + vinc movie 2t01xy2c1.gif" style="width: 256px; height: 256px" border=0 /></a> <br /> Kuan Yan (copyright 2008)<br /> <p /> </dd> <dt>Research Interests</dt> <dd> <li>High-throughput and high-content phenotype analysis</li> <li>Modeling and simulation of cell migration</li> <li>3D volume construction and slice alignment</li> <li>Self-adaptive segmentation</li> <li>High-content database management</li> </dd> </dl> </div> <div class="contentblock"> <a name="Publication"></a> <h2>Publication</h2> <br /> <b>Journal</b><br /> <dl> <dd> Yan, K. and Verbeek, F., (2011).<br/> "Watershed Masked Clustering Segmentation in High-throughput Image Analysis".<br/> <i>Pattern Recognition Journal</i>, [In 2<sup>nd</sup> Review] </dd> </dl> <dl> <dd> Qin, Y., Stokman, G., Yan, K., Ramaiahgari, S., Verbeek, F.J., de Graauw, M., van de Water, B., Price, L.S.(2011)<br/> "Cyclic AMP signalling protects proximal tubule epithelial cells from cisplatin-induced apoptosis via activation of Epac".<br/> <i>British Journal of Pharmacology</i>, 2011, doi: 10.1111/j.1476-5381.2011.01594.x. [Epub ahead of print] </dd> </dl> <dl> <dd> Damiano, L., Le D&eacute;v&eacute;dec, S.E., Di Stefano, P., Repetto, D., Lalai, R., Truong, H., Xiong, J.L., Danen, E.H., Yan, K., Verbeek, F.J., De Luca, E., Attanasio, F., Buccione, R., Turco, E., van de Water, B. and Defilippi, P.(2011)<br/> "p140Cap suppresses the invasive properties of highly metastatic MTLn3-EGFR cells via impaired cortactin phosphorylation".<br/> <i>Oncogene</i>, 2011, doi: 10.1038/onc.2011.257. [Epub ahead of print] </dd> </dl> <dl> <dd> Le D&eacute;v&eacute;dec, S.E., Yan K., de Bont H., Ghotra V., Truong H.,Danen E., Verbeek F.J., and vande Water B.(2010)<br/> "A Systems Microscopy Approach to Understand Cancer Cell Migration and Metastasis".<br/> <i>Cellular and Molecular in Life Science</i>, Volume 67, Issue 19, pp.3219-3240 </dd> </dl> <b>Proceeding</b><br /> <dl> <dd> Cao, L., Yan, K., Winkel, L., De Grauw, M. and Verbeek, F.J.(2011)<br> "Automation in Cytomics: Systematic Solution for Image Analysis and Management in High-throughput Screening Experiments".<br> <i>In Proc. of International Conference on Computational Biology and Bioinformatics (PRIB2011)</i>. [Accepted] </dd> </dl> <dl> <dd> Yan, K., Larios, E. and Verbeek, F.J.(2011)<br/> "Pattern Recogntion in High-Content Cytomics Screens for Target Discovery".<br/> <i>In Proc. of 6th IEEE International Conference on Pattern Recognition in Bioinformatics (CBB2011)</i>. [Accepted] </dd> </dl> <dl> <dd> Yan, K., Bertens, L., and Verbeek, F.J. (2010)<br/> "Image Registration and Realignment Using CMA-ES with High Resolution Vasculature Image Stack".<br/> <i>In Proc. of IASTED International Conference on Computer Graphics and Imaging (CGIM2010)</i>. </dd> </dl> <dl> <dd> Yan, K., LeD&eacute;v&eacute;dec, S., van de Water, B., Verbeek, F.J. (2009)<br/> "Cell Tracking and Data Analysis of in vitro Tumour Cells from Time-Lapse Image Sequences".<br/> <i>In Proc. of International Conference on Computer Vision Theory and Application (VISAPP2009)</i>. </dd> </dl> </div> <!-- meer <div class="contentblock"> <a name="VeranderDeAnchor"></a> <h2>Titel van het blok</h2> <p>Tekst gaat in paragrafen</p> <p>Etc.</p> </div> --> </div> </div> <p class="footer">2011 Kuan Yan (c)</body> </html>